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Conplast SP420 - Conventional superplasticising additive for high workability. Conventional superplasticising additive that allows extending the period of maintenance of workability. …
The PK data confirmed that the doses of SP-420 planned for the company's upcoming Phase 1-2 trial in patients with transfusional iron overload (TIO) should provide sufficient drug exposure for the ...
Our phase I, open-label, multi-center, dose-escalation study evaluated the pharmacokinetics (PK) of SP-420, a tridentate oral iron chelating agent of the desferrithiocin class, in patients with transfusion dependent β-thalassemia. SP-420 was administered as a single dose of 1.5 (n = 3), 3 (n = 3), 6 …
The grant award supports further testing of AbFero's lead compound in Parkinson's models with a goal of moving it into clinical trials. SP-420, a next-generation iron chelator, is believed safer and more tolerable than earlier versions, the U.K. group reports. "AbFero is working urgently to develop best-in-class, next generation iron …
Self-Clinching Nuts – Types S, SS, CLS, CLSS, SP. Type SP, PEM 300® nuts provide strong load-bearing threads in stainless steel sheets as thin as .030". Type SP is recommended for use in stainless steel sheets HRB (Rockwell "B" scale) 90 or less and HB (Hardness Brinell) 185 or less. Request Samples. CAD Files.
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SP-420 achieves high tissue exposure in key target organs and is a potentially safer alternative with greater efficacy, higher tolerability, and excellent oral bioavailability. SP …
You save $94.00! The new SP-420 smart pyranometer can be connected directly to a computer for taking spot measurements or graphing and datalogging real-time shortwave radiation using the included software. The sensor can also act as a stand-alone shortwave radiation datalogger by simply connecting it to most standard 5 V DC USB power sources.
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SP-420 is under clinical development by Abfero Pharmaceuticals and currently in Phase II for Beta Thalassaemia. According to GlobalData, Phase II drugs for Beta Thalassaemia have a 38% phase transition success rate (PTSR) indication benchmark for …
AbFero has completed three safety studies with SP-420 to date: R. Phase 1a in healthy volunteers (n=24) Single, ascending doses ranging from 1.67 to 13.2 mg/kg . R. Phase 1b in patients with transfusion-dependent β-thalassemia (n=24) Open-label, dose-escalation 1.5 to 24 mg/kg/day per day for up to 28 days R.
An Open-label, Dose-escalation, Dose-finding, and Proof-of-concept Trial of SP-420 in Subjects With Transfusion-dependent β-thalassemia. The goal of this clinical trial is to learn about SP-420 ability to remove iron from organs in subjects with transfusion-dependent β-thalassemia. The main questions it aims to answer are:
28940308. 10.1002/ajh.24914. Our phase I, open-label, multi-center, dose-escalation study evaluated the pharmacokinetics (PK) of SP-420, a tridentate oral iron chelating agent of …
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The development of SP-420, a novel oral iron chelator, may offer a new favorable treatment alternative in a convenient thrice-weekly dosing regimen. This week, the first patient has been enrolled into the trial which is planned to include patients with transfusion-dependent β-thalassemia from countries in North America, Europe, Middle …
SP 420. Alternative Names: SP-420. Latest Information Update: 06 Sep 2023. Price : $50 *. Buy Profile. Adis is an information provider. We do not sell or distribute actual drugs. Final gross price and currency may vary according to local VAT and billing address. Your purchase entitles you to full access to the information contained in our drug ...
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SP-420 Shortwave Radiation Measurement Example of total shortwave radiation measurement with an Apogee SP-510 pyranometer. Full sunlight yields total shortwave radiation on a horizontal plane at the Earth's surface of approximately 1000 W m⁻². This yields an output signal of 57.1 mV (varies from sensor to sensor). The signal
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SP-420 is a desferrithiocin analogue with iron-clearing efficiency with ICE value of 26. This phase I study assessed SP-420 in β-thalassemia patients. Plasma concentrations increased with dose. Renal adverse events, including proteinuria and increased serum creatinine, led to premature study termination.
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The primary objective of the Phase II trial is to assess the efficacy of SP-420 in removing iron from the body at three different dose levels. The main efficacy outcome …
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The trial design is of sufficient size and duration to establish SP-420 safety and efficacy in reducing liver iron content (LIC) caused by chronic red blood cell transfusions. The trial is expected to provide key data in 2021. "This is an important mile-marker for SP-420," said AbFero CEO Thomas X. Neenan.
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